Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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1,201 – 1,215 of 3,715 results

1,201

Apexbio Technology LLC DGAT-1 inhibitor 701232-20-4 200mg

DGAT-1 inhibitor (CAS 701232-20-4) also known as T863 is an orally active small molecule that selectively inhibits diacylglycerol acyltransferase 1 (DGAT1) DGAT1 is responsible for catalyzing the final step in triglyceride biosynthesis T863 suppresses enzyme activity by specifically binding to the acyl-CoA binding site of DGAT1 exhibiting an IC50 of 15 nM without affecting enzymatic activities of human DGAT2 MGAT2 or MGAT3 This compound serves as a research tool for investigating DGAT1-mediated lipid synthesis and exploring lipid metabolic disorders using cellular and animal models

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1,202

Apexbio Technology LLC PF-543 1415562-82-1 200mg

PF-543 (CAS 1415562-82-1) is a cell-permeable inhibitor targeting sphingosine kinase 1 (SphK1) an enzyme that phosphorylates sphingosine to sphingosine-1-phosphate (S1P) It displays potent inhibitory activity against SphK1 with an IC50 of 3 6 nM through sphingosine-competitive (non-ATP competitive) binding Treatment of SphK1-overexpressing head and neck cancer (1483) cells led to a ten-fold decrease in S1P levels confirming effective target engagement PF-543 is widely utilized as a research tool in studies investigating SphK1-mediated signaling pathways in cancer biology and immune cell trafficking

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1,203

Medchemexpress LLC Adagrasib | 2326521-71-3 | >99.9% | 200 MG

Adagrasib (MRTX849) is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. It covalently binds to KRAS G12C at the cysteine at residue 12, locking the protein in its inactive GDP-bound conformation and inhibiting KRAS-dependent signal transduction.

Potent and orally-available.
Mutation-selective covalent inhibitor of KRAS G12C.
Potential antineoplastic activity.
Inhibits KRAS-dependent signal transduction.

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1,204

TARGETMOL CHEMICALS INC 9-Phenanthrol 200MG

Also available in 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. 9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. Purity 98.72%

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1,205

Apexbio Technology LLC Cobicistat (GS-9350) 1004316-88-4 200mg

Cobicistat (GS-9350) is a selective inhibitor of cytochrome P450 3A enzyme (CYP3A) showing inhibitory activity with an IC50 ranging from 0 03 to 0 285 M in vitro It lacks intrinsic anti-HIV activity but serves primarily as a pharmacokinetic enhancer used in combination therapy to increase the systemic exposure of HIV-1 protease inhibitors such as atazanavir and darunavir Clinically cobicistat is administered orally to HIV-1-infected adults facilitating optimized dosing regimens Due to its selective CYP3A inhibitory mechanism cobicistat is employed in pharmacokinetic studies and drug-drug interaction investigations related to HIV treatments

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1,206

eMolecules 5-HYDROXYQUINOLINE-3-CARBOXYLIC ACID | 911108-90-2 | MFCD18417133 | 1g

AstaTech | 5-HYDROXYQUINOLINE-3-CARBOXYLIC ACID | 1g | 200618597 | 80318 | 95.000 | 911108-90-2 | MFCD18417133 | 189.170 | C10H7NO3

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1,207

TARGETMOL CHEMICALS INC Parthenolide 200MG

Also available in 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-kB inhibitor and also specifically inhibits HDAC1 protein, but is inactive against other class I/II HDACs. Parthenolide has anti-inflammatory, anti-tumor, and anti-viral activities. Purity 99.33%

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1,208

TARGETMOL CHEMICALS INC Levetiracetam 200MG

Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and to rare cases of clinically apparent drug induced liver disease. Purity 99.81%

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1,209

eMolecules 4-Hydroxyquinoline-2-carboxylic acid hydrate | 345909-35-5 | MFCD00149476 | 1g

Apollo Scientific | 4-Hydroxyquinoline-2-carboxylic acid hydrate | 1g | 562444254 | OR12784 | | 345909-35-5 | MFCD00149476 | 207.185 | C10H9NO4

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1,210

Medchemexpress LLC Disuccinimidyl sulfoxide | 1351828-03-9 | MFCD30497419 | 99.8% | 388.35 g·mol⁻¹ | C14H16N2O9S | 100MG

Disuccinimidyl sulfoxide (DSSO) is a homobifunctional, amine-targeting sulfoxide cross-linker designed for mass-spectrometry-based protein cross-linking and interaction mapping. Its CID-cleavable bonds produce characteristic fragmentation patterns that simplify identification of cross-linked peptides, making it suitable for studies of peptides, proteins, and multisubunit complexes.

MS-cleavable cross-linker that aids peptide identification
Homobifunctional, amine-reactive chemistry for lysine targeting
CID-cleavable sites generate characteristic fragmentation patterns
Suitable for peptides, proteins, and multisubunit complexes
Supplied as a crystalline solid for solution preparation
High purity for analytical mass spectrometry

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1,211

TARGETMOL CHEMICALS INC Insulin human 200MG

Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin (human) has hypoglycemic activity and is used clinically to treat hyperglycemia in diabetic patients. Purity 99.99%

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1,212

Medchemexpress LLC Sulfo-Cy3(Me)COOH | 1121756-11-3 | 95.0% | 616.75 g·mol⁻¹ | C30H36N2O8S2 | 10 MG

Sulfo-Cy3(Me)COOH is a sulfonated cyanine3 derivative supplied as a green to dark green solid. It is an orange-fluorescent labeling reagent for proteins and nucleic acids, with excitation at ~554 nm and emission at ~568 nm. The compound is water-soluble and is provided at 10 mg with high purity, intended for conjugation and fluorescence assay applications and requiring protection from light.

Orange-fluorescent label: Ex = 554 nm, Em = 568 nm.
High purity suitable for conjugation: ~95.0%.
Water-soluble: H2O solubility 125 mg/mL (ultrasonic may be required).
Appearance: solid, green to dark green.
Storage: 4°C protected from light; in solvent -80°C (6 months) or -20°C (1 month).
Typical applications: labeling of proteins and nucleic acids, fluorescence assays, conjugation chemistry.

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1,213

Medchemexpress LLC Amikacin (standard) | 37517-28-5 | 99.9% | 200 MG

Amikacin is a semisynthetic kanamycin analog that is effective against most Gram-negative bacteria, including strains resistant to gentamicin and tobramycin. It exhibits a significant inhibitory effect and can be utilized in bacteriostatic, anti-cancer, and analgesic studies.

Semisynthetic kanamycin analog
Effective against most Gram-negative bacteria
Exhibits significant inhibitory effect
Can be utilized in bacteriostatic, anti-cancer, and analgesic studies
Appearance: solid, white to off-white
Purity: 99.9%
Molecular weight: 585.60
Formula: C22H43N5O13
Recommended storage: 4°C, sealed and dry, away from moisture
Shipping: room temperature in continental US
Stable under recommended storage conditions

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1,214

eMolecules 2-HYDROXYQUINOLINE-6-CARBOXYLIC ACID | 70639-78-0 | MFCD11007961 | 1g

AstaTech | 2-HYDROXYQUINOLINE-6-CARBOXYLIC ACID | 1g | 323612351 | K10089 | 95.000 | 70639-78-0 | MFCD11007961 | 189.170 | C10H7NO3

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1,215

Medchemexpress LLC 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[2-(1-azetidinylsulfonyl)phenyl]-7-methyl-2-(3-methyl | 3055550-22-3 | 99.9% | 423.49 g·mol⁻¹ | C20H21N7O2S | 10 MG

EGFR-IN-86 is a small-molecule epidermal growth factor receptor (EGFR) inhibitor reported to have an IC50 of 1.5 nM. It has demonstrated activity in glioblastoma models, inducing apoptosis and causing G2/M cell-cycle arrest in U87 cells. Supplied as a high-purity research compound (99.92%), it is intended for in vitro and preclinical studies. Molecular formula C20H21N7O2S; molecular weight 423.49 g·mol⁻¹.

Potent EGFR inhibition with a reported IC50 of 1.5 nM.
Demonstrated activity in glioblastoma models, inducing apoptosis.
Induces G2/M cell-cycle arrest in U87 cells.
High purity suitable for research applications.
Supplied in small research-friendly quantities for laboratory use.
Molecular formula C20H21N7O2S and molecular weight 423.49 g·mol⁻¹.

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Quinolines and derivatives

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Apexbio Technology LLC DGAT-1 inhibitor 701232-20-4 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC PF-543 1415562-82-1 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Adagrasib | 2326521-71-3 | >99.9% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC 9-Phenanthrol 200MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Cobicistat (GS-9350) 1004316-88-4 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC Parthenolide 200MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC Levetiracetam 200MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Disuccinimidyl sulfoxide | 1351828-03-9 | MFCD30497419 | 99.8% | 388.35 g·mol⁻¹ | C14H16N2O9S | 100MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC Insulin human 200MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Sulfo-Cy3(Me)COOH | 1121756-11-3 | 95.0% | 616.75 g·mol⁻¹ | C30H36N2O8S2 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Amikacin (standard) | 37517-28-5 | 99.9% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[2-(1-azetidinylsulfonyl)phenyl]-7-methyl-2-(3-methyl | 3055550-22-3 | 99.9% | 423.49 g·mol⁻¹ | C20H21N7O2S | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More